Paracellular Transport of Soybean β‐Conglycinin using a Caco‐2/HT29‐MTX Co‐Culture
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چکیده
منابع مشابه
Increased urothelial paracellular transport promotes cystitis.
Changes in the urothelial barrier are observed in patients with cystitis, but whether this leads to inflammation or occurs in response to it is currently unknown. To determine whether urothelial barrier dysfunction is sufficient to promote cystitis, we employed in situ adenoviral transduction to selectively overexpress the pore-forming tight junction-associated protein claudin-2 (CLDN-2). As ex...
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Epithelia separate apical and basal compartments, and movement of substances via the paracellular pathway is regulated by tight junctions. Claudins are major constituents of tight junctions and involved in the regulation of tight junction permeability. On the other hand, the osmolality in the extracellular environment fluctuates in association with life activity. However, effects of osmotic cha...
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The syncytial epithelium of parasitic flatworms offers the opportunity to examine epithelial transport physiology in the absence of paracellular pathways. The asymmetric enzymatic and permeability properties of the apical and basal membranes confirm the transepithelial transport function of the syncytial epithelium. Although the absence of a paracellular pathway has led to the suggestion that t...
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The morphological change of the paracellular route for fluid secretion is still a long-standing question. The purpose of this study was to visualize alterations in the cytoskeleton structure of tight junctions caused by carbachol (CCh) and isoproterenol (IPR) treatment of perfused rat submandibular glands (SMGs), using freeze-fracture (FF) replicas of rapidly frozen tissues. Isolated SMGs from ...
متن کاملUnderstanding the Role of Paracellular Transport in the Proximal Tubule.
Fluid and solute reabsorption by the proximal tubule is the result of both transcellular and paracellular flux. The role of transcellular transport has been extensively studied, but the importance of paracellular flux has not been as thoroughly investigated. The purpose of this review is to update concepts about the contribution of paracellular transport for reabsorption by the proximal tubule.
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2013
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.27.1_supplement.794.10